Drug interactions
Lasmiditan + Quinidine
Severity: Moderate
Lasmiditan and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may raise levels of P-gp substrates such as quinidine. Since quinidine has a narrow therapeutic index, a small rise in exposure could matter, but the clinical effect is not well characterized.
What this interaction means in plain words
Lasmiditan and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Lasmiditan may inhibit P-glycoprotein, reducing quinidine efflux and increasing exposure.
What to do
Monitor ECG and for signs of quinidine toxicity if lasmiditan is used. Consider an alternative migraine therapy in patients with QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Quinidine?
MediHelp rates the interaction as moderate. Lasmiditan and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro and may raise levels of P-gp substrates such as quinidine. Since quinidine has a narrow therapeutic index, a small rise in exposure could matter, but the clinical effect is not well characterized.
How serious is the interaction between Lasmiditan and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for signs of quinidine toxicity if lasmiditan is used. Consider an alternative migraine therapy in patients with QT risk.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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