Drug interactions
Lasmiditan + Sertraline
Severity: Moderate
Lasmiditan and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan is a 5-HT1F agonist that causes dizziness and sedation, and sertraline adds CNS effects. Although lasmiditan lacks vasoconstrictive activity, serotonin syndrome has been a labeled theoretical concern with serotonergic drugs.
What this interaction means in plain words
Lasmiditan and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive CNS depression and possible additive serotonergic effects.
What to do
Advise patients not to drive for at least 8 hours after a lasmiditan dose. Monitor for symptoms of serotonin syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Sertraline?
MediHelp rates the interaction as moderate. Lasmiditan and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan is a 5-HT1F agonist that causes dizziness and sedation, and sertraline adds CNS effects. Although lasmiditan lacks vasoconstrictive activity, serotonin syndrome has been a labeled theoretical concern with serotonergic drugs.
How serious is the interaction between Lasmiditan and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive for at least 8 hours after a lasmiditan dose. Monitor for symptoms of serotonin syndrome.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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