Drug interactions
Lasmiditan + Tranylcypromine
Severity: Moderate
Lasmiditan and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan is a selective 5-HT1F agonist that causes sedation and dizziness, and it may add to CNS depression from an MAO inhibitor. A serotonin syndrome risk is theoretical, since lasmiditan lacks vasoconstrictive 5-HT1B/1D activity but acts on the serotonin system.
What this interaction means in plain words
Lasmiditan and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, plus a theoretical serotonergic contribution from combining a serotonin receptor agonist with an MAO inhibitor.
What to do
Advise patients about sedation and impaired driving for at least 8 hours after lasmiditan, and monitor for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Tranylcypromine?
MediHelp rates the interaction as moderate. Lasmiditan and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan is a selective 5-HT1F agonist that causes sedation and dizziness, and it may add to CNS depression from an MAO inhibitor. A serotonin syndrome risk is theoretical, since lasmiditan lacks vasoconstrictive 5-HT1B/1D activity but acts on the serotonin system.
How serious is the interaction between Lasmiditan and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about sedation and impaired driving for at least 8 hours after lasmiditan, and monitor for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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