Drug interactions
Lasmiditan + Vinblastine
Severity: Moderate
Lasmiditan and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may increase vinblastine exposure. Lasmiditan is used intermittently for migraine, so the effect is likely limited and a clinically relevant interaction is uncertain.
What this interaction means in plain words
Lasmiditan and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Vinblastine belongs to Oncology.
Why it happens
Lasmiditan inhibits P-gp efflux, which may raise vinblastine concentrations.
What to do
Avoid lasmiditan on days of vinblastine administration if feasible. Monitor for increased myelosuppression and neurotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Vinblastine?
MediHelp rates the interaction as moderate. Lasmiditan and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro and may increase vinblastine exposure. Lasmiditan is used intermittently for migraine, so the effect is likely limited and a clinically relevant interaction is uncertain.
How serious is the interaction between Lasmiditan and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid lasmiditan on days of vinblastine administration if feasible. Monitor for increased myelosuppression and neurotoxicity.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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