Drug interactions
Latanoprost + Naproxen
Severity: Minor
Latanoprost and Naproxen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reports on the effect of NSAIDs on the pressure-lowering action of prostaglandin eye drops are inconsistent, with some suggesting a reduced effect and others an enhanced one. The interaction is poorly characterized and unlikely to cause serious harm.
What this interaction means in plain words
Latanoprost and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Latanoprost belongs to Miscellaneous; Naproxen belongs to Musculoskeletal.
Why it happens
Mechanism is not established; NSAID inhibition of prostaglandin synthesis may modulate the uveoscleral outflow effect of latanoprost.
What to do
No routine change is needed; check intraocular pressure at usual follow-up visits if systemic naproxen is started or stopped in a glaucoma patient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Latanoprost
- Bimatoprost + Latanoprost Moderate
- Latanoprost + Latanoprostene bunod Moderate
- Latanoprost + Tafluprost Moderate
- Latanoprost + Travoprost Moderate
- Aspirin rectal + Latanoprost Minor
- Aspirin + Latanoprost Minor
Frequently asked questions
Can I take Latanoprost with Naproxen?
MediHelp rates the interaction as minor. Latanoprost and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reports on the effect of NSAIDs on the pressure-lowering action of prostaglandin eye drops are inconsistent, with some suggesting a reduced effect and others an enhanced one. The interaction is poorly characterized and unlikely to cause serious harm.
How serious is the interaction between Latanoprost and Naproxen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check intraocular pressure at usual follow-up visits if systemic naproxen is started or stopped in a glaucoma patient.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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