Drug interactions
Ledipasvir-sofosbuvir + Vadadustat
Severity: Minor
Ledipasvir-sofosbuvir and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and may increase exposure to ledipasvir and sofosbuvir. The effect is expected to be modest.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ledipasvir-sofosbuvir belongs to Anti Virals; Vadadustat belongs to Endocrine.
Why it happens
BCRP inhibition by vadadustat reduces intestinal efflux of ledipasvir/sofosbuvir.
What to do
Monitor for antiviral adverse effects; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Vadadustat?
MediHelp rates the interaction as minor. Ledipasvir-sofosbuvir and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits BCRP and may increase exposure to ledipasvir and sofosbuvir. The effect is expected to be modest.
How serious is the interaction between Ledipasvir-sofosbuvir and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antiviral adverse effects; no routine dose change is needed.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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