Drug interactions
Leflunomide + Meningococcal group b vaccine
Severity: Minor
Leflunomide and Meningococcal group b vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide-related immunosuppression may reduce the antibody response to meningococcal B vaccine. The vaccine is non-live and can be given, but protection may be incomplete.
What this interaction means in plain words
Leflunomide and Meningococcal group b vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Leflunomide's inhibition of lymphocyte proliferation may reduce vaccine immunogenicity.
What to do
Give the vaccine according to the schedule and do not delay it. Consider checking the response where it is clinically important.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Leflunomide with Meningococcal group b vaccine?
MediHelp rates the interaction as minor. Leflunomide and Meningococcal group b vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leflunomide-related immunosuppression may reduce the antibody response to meningococcal B vaccine. The vaccine is non-live and can be given, but protection may be incomplete.
How serious is the interaction between Leflunomide and Meningococcal group b vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine according to the schedule and do not delay it. Consider checking the response where it is clinically important.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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