Drug interactions
Leflunomide + Ofatumumab sc
Severity: Moderate
Leflunomide and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells, and leflunomide is also immunosuppressive. Combined use may increase the risk of serious infections.
What this interaction means in plain words
Leflunomide and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and DHODH inhibition.
What to do
Avoid starting ofatumumab while leflunomide's effect persists unless benefit outweighs risk, and consider accelerated elimination of leflunomide when switching. Monitor for infections and check blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Leflunomide with Ofatumumab sc?
MediHelp rates the interaction as moderate. Leflunomide and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells, and leflunomide is also immunosuppressive. Combined use may increase the risk of serious infections.
How serious is the interaction between Leflunomide and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ofatumumab while leflunomide's effect persists unless benefit outweighs risk, and consider accelerated elimination of leflunomide when switching. Monitor for infections and check blood counts.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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