Drug interactions
Leflunomide + Poliovirus vaccine inactivated
Severity: Minor
Leflunomide and Poliovirus vaccine inactivated: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide may reduce the antibody response to inactivated poliovirus vaccine. The vaccine is non-live, so the issue is diminished protection.
What this interaction means in plain words
Leflunomide and Poliovirus vaccine inactivated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Leflunomide's lymphocyte antiproliferative action reduces vaccine immunogenicity.
What to do
Vaccinate before starting leflunomide if possible. Consider checking immunity or revaccinating if protection is essential.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Leflunomide with Poliovirus vaccine inactivated?
MediHelp rates the interaction as minor. Leflunomide and Poliovirus vaccine inactivated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leflunomide may reduce the antibody response to inactivated poliovirus vaccine. The vaccine is non-live, so the issue is diminished protection.
How serious is the interaction between Leflunomide and Poliovirus vaccine inactivated?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting leflunomide if possible. Consider checking immunity or revaccinating if protection is essential.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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