Drug interactions
Leflunomide + Ponatinib
Severity: Moderate
Leflunomide and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits BCRP and may increase exposure to teriflunomide, the active metabolite of leflunomide. Both drugs can be hepatotoxic and myelosuppressive, so higher exposure may increase toxicity.
What this interaction means in plain words
Leflunomide and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leflunomide belongs to Musculoskeletal; Ponatinib belongs to Oncology.
Why it happens
Ponatinib inhibits BCRP efflux, possibly raising teriflunomide levels, together with additive toxicities.
What to do
Monitor liver enzymes and complete blood counts closely. Reduce the leflunomide dose or stop it if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Leflunomide with Ponatinib?
MediHelp rates the interaction as moderate. Leflunomide and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits BCRP and may increase exposure to teriflunomide, the active metabolite of leflunomide. Both drugs can be hepatotoxic and myelosuppressive, so higher exposure may increase toxicity.
How serious is the interaction between Leflunomide and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and complete blood counts closely. Reduce the leflunomide dose or stop it if toxicity develops.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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