Drug interactions
Leflunomide + Rabies vaccine chick embryo cell derived
Severity: Moderate
Leflunomide and Rabies vaccine chick embryo cell derived: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide-induced suppression of lymphocyte proliferation may blunt the antibody response to rabies vaccination. Because rabies vaccine is inactivated, there is no risk of vaccine-strain infection, but protective titres may be inadequate. This matters most for post-exposure prophylaxis.
What this interaction means in plain words
Leflunomide and Rabies vaccine chick embryo cell derived can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of dihydroorotate dehydrogenase reduces activated T and B lymphocyte proliferation, impairing vaccine immune response.
What to do
Do not withhold vaccination when exposure risk exists; give the full schedule and check rabies neutralising antibody titres afterwards. Where feasible, give pre-exposure vaccination before starting leflunomide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Leflunomide with Rabies vaccine chick embryo cell derived?
MediHelp rates the interaction as moderate. Leflunomide and Rabies vaccine chick embryo cell derived can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leflunomide-induced suppression of lymphocyte proliferation may blunt the antibody response to rabies vaccination. Because rabies vaccine is inactivated, there is no risk of vaccine-strain infection, but protective titres may be inadequate. This matters most for post-exposure prophylaxis.
How serious is the interaction between Leflunomide and Rabies vaccine chick embryo cell derived?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold vaccination when exposure risk exists; give the full schedule and check rabies neutralising antibody titres afterwards. Where feasible, give pre-exposure vaccination before starting leflunomide.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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