Drug interactions
Leflunomide + Rabies vaccine
Severity: Moderate
Leflunomide and Rabies vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide may reduce antibody response to rabies vaccine, which is important when used for post-exposure prophylaxis.
What this interaction means in plain words
Leflunomide and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antiproliferative immunosuppression may dampen humoral vaccine response.
What to do
Do not delay post-exposure vaccination; check rabies neutralising antibody titres afterwards and give immune globulin as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Leflunomide with Rabies vaccine?
MediHelp rates the interaction as moderate. Leflunomide and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leflunomide may reduce antibody response to rabies vaccine, which is important when used for post-exposure prophylaxis.
How serious is the interaction between Leflunomide and Rabies vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not delay post-exposure vaccination; check rabies neutralising antibody titres afterwards and give immune globulin as indicated.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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