Drug interactions
Leflunomide + Tetanus toxoid adsorbed or fluid
Severity: Minor
Leflunomide and Tetanus toxoid adsorbed or fluid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetanus toxoid is non-replicating, so there is no infection risk, though the antibody response may be reduced in a patient taking leflunomide. This is a reduced-efficacy concern rather than a safety hazard. Vaccination remains recommended.
What this interaction means in plain words
Leflunomide and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced lymphocyte proliferation from dihydroorotate dehydrogenase inhibition may blunt antibody production.
What to do
Vaccinate as indicated without delay. In a tetanus-prone wound, give immunoglobulin and boosters per standard protocols regardless of leflunomide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Leflunomide with Tetanus toxoid adsorbed or fluid?
MediHelp rates the interaction as minor. Leflunomide and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetanus toxoid is non-replicating, so there is no infection risk, though the antibody response may be reduced in a patient taking leflunomide. This is a reduced-efficacy concern rather than a safety hazard. Vaccination remains recommended.
How serious is the interaction between Leflunomide and Tetanus toxoid adsorbed or fluid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated without delay. In a tetanus-prone wound, give immunoglobulin and boosters per standard protocols regardless of leflunomide.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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