Drug interactions
Leflunomide + Typhoid polysaccharide vaccine
Severity: Minor
Leflunomide and Typhoid polysaccharide vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The typhoid Vi polysaccharide vaccine is non-live and safe, but immunosuppression from leflunomide may lower the antibody response. Protection may be incomplete in travellers to endemic regions.
What this interaction means in plain words
Leflunomide and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced lymphocyte proliferation from dihydroorotate dehydrogenase inhibition may impair antibody generation.
What to do
Give the vaccine at least about two weeks before travel and advise strict food and water precautions. Do not use the live oral typhoid vaccine as a substitute.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Leflunomide with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as minor. Leflunomide and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The typhoid Vi polysaccharide vaccine is non-live and safe, but immunosuppression from leflunomide may lower the antibody response. Protection may be incomplete in travellers to endemic regions.
How serious is the interaction between Leflunomide and Typhoid polysaccharide vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least about two weeks before travel and advise strict food and water precautions. Do not use the live oral typhoid vaccine as a substitute.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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