Drug interactions
Lemborexant + Losartan
Severity: Minor
Lemborexant and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan is regarded here as a weak CYP3A4 inhibitor and might raise lemborexant exposure. This could increase next-day somnolence and impaired alertness.
What this interaction means in plain words
Lemborexant and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lemborexant belongs to Central Nervous System; Losartan belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated lemborexant metabolism.
What to do
Counsel on next-day drowsiness and driving. Follow lemborexant labeling for dose limits with weak CYP3A4 inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lemborexant and Losartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Losartan?
MediHelp rates the interaction as minor. Lemborexant and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Losartan is regarded here as a weak CYP3A4 inhibitor and might raise lemborexant exposure. This could increase next-day somnolence and impaired alertness.
How serious is the interaction between Lemborexant and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on next-day drowsiness and driving. Follow lemborexant labeling for dose limits with weak CYP3A4 inhibitors.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
