Drug interactions
Lemborexant + Lovastatin
Severity: Minor
Lemborexant and Lovastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lovastatin is a weak CYP3A4 inhibitor at best, so it may modestly raise lemborexant levels, which are CYP3A4 dependent. This could increase next-day somnolence and impaired alertness.
What this interaction means in plain words
Lemborexant and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lemborexant belongs to Central Nervous System; Lovastatin belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated lemborexant metabolism.
What to do
No routine change is needed; monitor for daytime drowsiness and reduce the lemborexant dose if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Lovastatin?
MediHelp rates the interaction as minor. Lemborexant and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lovastatin is a weak CYP3A4 inhibitor at best, so it may modestly raise lemborexant levels, which are CYP3A4 dependent. This could increase next-day somnolence and impaired alertness.
How serious is the interaction between Lemborexant and Lovastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for daytime drowsiness and reduce the lemborexant dose if excessive sedation occurs.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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