Drug interactions
Lemborexant + Meperidine
Severity: Moderate
Lemborexant and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is a sedative-hypnotic and meperidine depresses the CNS, so the combination can cause additive drowsiness and psychomotor impairment. This increases the risk of next-day impairment and falls.
What this interaction means in plain words
Lemborexant and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression via orexin receptor antagonism and opioid receptor agonism.
What to do
Use the lowest effective doses and consider lowering the lemborexant dose. Counsel patients about impaired driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Meperidine?
MediHelp rates the interaction as moderate. Lemborexant and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is a sedative-hypnotic and meperidine depresses the CNS, so the combination can cause additive drowsiness and psychomotor impairment. This increases the risk of next-day impairment and falls.
How serious is the interaction between Lemborexant and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and consider lowering the lemborexant dose. Counsel patients about impaired driving and fall risk.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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