Drug interactions
Lemborexant + Midazolam
Severity: Moderate
Lemborexant and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam can modestly raise lemborexant exposure through CYP3A4 inhibition, and both agents are sedating. The combination can increase next-day somnolence and impair psychomotor performance.
What this interaction means in plain words
Lemborexant and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression plus weak CYP3A4 inhibition by midazolam that reduces lemborexant clearance.
What to do
Use the lowest effective lemborexant dose and monitor for excess sedation. Counsel the patient on next-day impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lemborexant and Midazolam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Midazolam?
MediHelp rates the interaction as moderate. Lemborexant and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam can modestly raise lemborexant exposure through CYP3A4 inhibition, and both agents are sedating. The combination can increase next-day somnolence and impair psychomotor performance.
How serious is the interaction between Lemborexant and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and monitor for excess sedation. Counsel the patient on next-day impairment.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
