Drug interactions
Lemborexant + Omeprazole
Severity: Minor
Lemborexant and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Weak CYP3A4 inhibitors can raise lemborexant levels, increasing next-day somnolence. Omeprazole has only weak CYP3A4 inhibition, so the effect is likely small.
What this interaction means in plain words
Lemborexant and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lemborexant belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition reduces lemborexant metabolism.
What to do
Monitor for daytime drowsiness and limit lemborexant to the labeled lower dose if a weak CYP3A4 inhibitor is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Omeprazole?
MediHelp rates the interaction as minor. Lemborexant and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Weak CYP3A4 inhibitors can raise lemborexant levels, increasing next-day somnolence. Omeprazole has only weak CYP3A4 inhibition, so the effect is likely small.
How serious is the interaction between Lemborexant and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime drowsiness and limit lemborexant to the labeled lower dose if a weak CYP3A4 inhibitor is used.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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