Drug interactions
Lemborexant + Sirolimus
Severity: Moderate
Lemborexant and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus is a weak CYP3A4 inhibitor and may increase lemborexant exposure. This could cause greater next-day somnolence and impaired alertness.
What this interaction means in plain words
Lemborexant and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP3A4 by sirolimus reduces lemborexant clearance.
What to do
Limit lemborexant to the reduced maximum nightly dose recommended for weak CYP3A4 inhibitors and counsel about next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Sirolimus?
MediHelp rates the interaction as moderate. Lemborexant and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus is a weak CYP3A4 inhibitor and may increase lemborexant exposure. This could cause greater next-day somnolence and impaired alertness.
How serious is the interaction between Lemborexant and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the reduced maximum nightly dose recommended for weak CYP3A4 inhibitors and counsel about next-day drowsiness.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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