Drug interactions
Lenacapavir + Losartan
Severity: Minor
Lenacapavir and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, which may increase exposure to CYP3A4 substrates, including losartan parent drug. Since losartan is also activated by CYP2C9 and the effect on the active metabolite is uncertain, clinical impact is likely small.
What this interaction means in plain words
Lenacapavir and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenacapavir belongs to Anti Virals; Losartan belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 by lenacapavir reducing losartan metabolism.
What to do
Monitor blood pressure and adverse effects such as hypotension or hyperkalemia when starting lenacapavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Losartan?
MediHelp rates the interaction as minor. Lenacapavir and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor, which may increase exposure to CYP3A4 substrates, including losartan parent drug. Since losartan is also activated by CYP2C9 and the effect on the active metabolite is uncertain, clinical impact is likely small.
How serious is the interaction between Lenacapavir and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adverse effects such as hypotension or hyperkalemia when starting lenacapavir.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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