Drug interactions
Lenacapavir + Lurasidone
Severity: Major
Lenacapavir and Lurasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, so it can raise lurasidone concentrations and the risk of dose-related adverse effects. The effect may persist for months after subcutaneous lenacapavir because of its long half-life.
What this interaction means in plain words
Lenacapavir and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lenacapavir belongs to Anti Virals; Lurasidone belongs to Central Nervous System.
Why it happens
Lenacapavir inhibits CYP3A4, reducing the metabolism of lurasidone, a sensitive CYP3A4 substrate.
What to do
Apply the lurasidone dose reduction recommended for moderate CYP3A inhibitors and monitor for sedation, akathisia and extrapyramidal symptoms, including during the months after the last lenacapavir injection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Lurasidone?
MediHelp rates the interaction as major. Lenacapavir and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lenacapavir is a moderate CYP3A inhibitor, so it can raise lurasidone concentrations and the risk of dose-related adverse effects. The effect may persist for months after subcutaneous lenacapavir because of its long half-life.
How serious is the interaction between Lenacapavir and Lurasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Apply the lurasidone dose reduction recommended for moderate CYP3A inhibitors and monitor for sedation, akathisia and extrapyramidal symptoms, including during the months after the last lenacapavir injection.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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