Drug interactions
Lenacapavir + Rimegepant
Severity: Moderate
Lenacapavir and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may increase rimegepant exposure. This could raise the risk of adverse effects.
What this interaction means in plain words
Lenacapavir and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of rimegepant by lenacapavir.
What to do
If rimegepant is taken for acute migraine, avoid a second dose within 48 hours. No adjustment is needed for preventive use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Rimegepant?
MediHelp rates the interaction as moderate. Lenacapavir and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may increase rimegepant exposure. This could raise the risk of adverse effects.
How serious is the interaction between Lenacapavir and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If rimegepant is taken for acute migraine, avoid a second dose within 48 hours. No adjustment is needed for preventive use.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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