Drug interactions
Lenacapavir + Saxagliptin
Severity: Moderate
Lenacapavir and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor with a long-lasting effect after subcutaneous dosing, which may raise saxagliptin exposure. The interaction can persist for months after the last lenacapavir injection.
What this interaction means in plain words
Lenacapavir and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Saxagliptin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 by lenacapavir reduces saxagliptin metabolism.
What to do
Monitor for saxagliptin adverse effects and glycemic response; consider saxagliptin 2.5 mg daily if increased exposure is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Saxagliptin?
MediHelp rates the interaction as moderate. Lenacapavir and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor with a long-lasting effect after subcutaneous dosing, which may raise saxagliptin exposure. The interaction can persist for months after the last lenacapavir injection.
How serious is the interaction between Lenacapavir and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for saxagliptin adverse effects and glycemic response; consider saxagliptin 2.5 mg daily if increased exposure is a concern.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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