Drug interactions
Lenacapavir + Solifenacin
Severity: Moderate
Lenacapavir and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may increase solifenacin concentrations. The effect may persist for months after the last subcutaneous dose because of its long half-life.
What this interaction means in plain words
Lenacapavir and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Solifenacin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 by lenacapavir decreases solifenacin clearance.
What to do
Monitor for anticholinergic adverse effects and QT prolongation, and consider a lower solifenacin dose, including during the months after the last lenacapavir injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Solifenacin?
MediHelp rates the interaction as moderate. Lenacapavir and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may increase solifenacin concentrations. The effect may persist for months after the last subcutaneous dose because of its long half-life.
How serious is the interaction between Lenacapavir and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and QT prolongation, and consider a lower solifenacin dose, including during the months after the last lenacapavir injection.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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