Drug interactions
Lenalidomide + Selinexor
Severity: Moderate
Lenalidomide and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are used in myeloma and are commonly combined with dexamethasone. Overlapping toxicities include fatigue, cytopenias (particularly thrombocytopenia) and neurological effects such as dizziness and confusion, so combined use needs dose management rather than being absolutely avoided.
What this interaction means in plain words
Lenalidomide and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenalidomide belongs to Oncology; Selinexor belongs to Oncology.
Why it happens
Additive pharmacodynamic toxicity including myelosuppression and CNS effects; no pharmacokinetic mechanism established.
What to do
Monitor blood counts, nausea and neurological symptoms, and reduce selinexor or lenalidomide doses per labeling when toxicity occurs; counsel patients on fall and driving risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lenalidomide
- Deferiprone + Lenalidomide Major
- Lenalidomide + Ropeginterferon alfa 2b Major
- Acalabrutinib + Lenalidomide Moderate
- Anakinra + Lenalidomide Moderate
- Cholera vaccine + Lenalidomide Moderate
- Denosumab + Lenalidomide Moderate
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Lenalidomide with Selinexor?
MediHelp rates the interaction as moderate. Lenalidomide and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are used in myeloma and are commonly combined with dexamethasone. Overlapping toxicities include fatigue, cytopenias (particularly thrombocytopenia) and neurological effects such as dizziness and confusion, so combined use needs dose management rather than being absolutely avoided.
How serious is the interaction between Lenalidomide and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, nausea and neurological symptoms, and reduce selinexor or lenalidomide doses per labeling when toxicity occurs; counsel patients on fall and driving risk.
What other medicines interact with Lenalidomide?
MediHelp also lists interactions of Lenalidomide with, for example, Deferiprone, Ropeginterferon alfa 2b, Acalabrutinib. The full list is on the Lenalidomide page.
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