Drug interactions
Leniolisib + Letermovir
Severity: Moderate
Leniolisib and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1, OATP1B3 and BCRP and may increase exposure to substrates such as letermovir, raising the risk of letermovir adverse effects.
What this interaction means in plain words
Leniolisib and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of hepatic uptake and efflux transporters by leniolisib raises letermovir concentrations.
What to do
Monitor for letermovir adverse effects such as gastrointestinal symptoms and consider whether the combination is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leniolisib
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Leniolisib with Letermovir?
MediHelp rates the interaction as moderate. Leniolisib and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1, OATP1B3 and BCRP and may increase exposure to substrates such as letermovir, raising the risk of letermovir adverse effects.
How serious is the interaction between Leniolisib and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for letermovir adverse effects such as gastrointestinal symptoms and consider whether the combination is needed.
What other medicines interact with Leniolisib?
MediHelp also lists interactions of Leniolisib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Leniolisib page.
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