Drug interactions
Leniolisib + Lovastatin
Severity: Moderate
Leniolisib and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits hepatic OATP1B1 and OATP1B3 uptake transporters, which may reduce hepatic uptake of statins and raise their systemic levels. Higher lovastatin exposure increases the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Leniolisib and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Lovastatin belongs to Cardiovascular.
Why it happens
Leniolisib inhibits OATP1B1/1B3-mediated hepatic uptake of lovastatin and its acid metabolite.
What to do
Use the lowest effective lovastatin dose, or consider a statin less dependent on OATP such as fluvastatin. Monitor for muscle symptoms and check CK if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Lovastatin?
MediHelp rates the interaction as moderate. Leniolisib and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits hepatic OATP1B1 and OATP1B3 uptake transporters, which may reduce hepatic uptake of statins and raise their systemic levels. Higher lovastatin exposure increases the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Leniolisib and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lovastatin dose, or consider a statin less dependent on OATP such as fluvastatin. Monitor for muscle symptoms and check CK if they occur.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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