Drug interactions
Leniolisib + Nitrofurantoin
Severity: Minor
Leniolisib and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and may raise exposure to BCRP substrates such as nitrofurantoin. The effect on nitrofurantoin has not been well characterized.
What this interaction means in plain words
Leniolisib and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Leniolisib belongs to Miscellaneous; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
BCRP inhibition may reduce efflux of nitrofurantoin and raise its systemic exposure.
What to do
Monitor for nitrofurantoin adverse effects such as gastrointestinal upset or neuropathy. Limit the antibiotic course to what is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Nitrofurantoin?
MediHelp rates the interaction as minor. Leniolisib and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits BCRP and may raise exposure to BCRP substrates such as nitrofurantoin. The effect on nitrofurantoin has not been well characterized.
How serious is the interaction between Leniolisib and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nitrofurantoin adverse effects such as gastrointestinal upset or neuropathy. Limit the antibiotic course to what is needed.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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