Drug interactions
Leniolisib + Pravastatin
Severity: Moderate
Leniolisib and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3 and may raise pravastatin concentrations. This could increase the risk of statin-related muscle toxicity.
What this interaction means in plain words
Leniolisib and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Pravastatin belongs to Cardiovascular.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake decreases pravastatin hepatic clearance.
What to do
Monitor for muscle pain or weakness and consider a lower pravastatin dose. Check CK if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Leniolisib and Pravastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pravastatin
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Pravastatin?
MediHelp rates the interaction as moderate. Leniolisib and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1 and OATP1B3 and may raise pravastatin concentrations. This could increase the risk of statin-related muscle toxicity.
How serious is the interaction between Leniolisib and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain or weakness and consider a lower pravastatin dose. Check CK if symptoms develop.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
