Drug interactions
Leniolisib + Rosuvastatin
Severity: Moderate
Leniolisib and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP, OATP1B1 and OATP1B3 and may increase rosuvastatin exposure. This raises the risk of muscle toxicity.
What this interaction means in plain words
Leniolisib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of BCRP and OATP transporters reduces rosuvastatin efflux and hepatic uptake.
What to do
Monitor for myopathy and consider reducing the rosuvastatin dose. Check CK if muscle symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Rosuvastatin?
MediHelp rates the interaction as moderate. Leniolisib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP, OATP1B1 and OATP1B3 and may increase rosuvastatin exposure. This raises the risk of muscle toxicity.
How serious is the interaction between Leniolisib and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myopathy and consider reducing the rosuvastatin dose. Check CK if muscle symptoms occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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