Drug interactions
Leniolisib + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Minor
Leniolisib and Sofosbuvir-velpatasvir-voxilaprevir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP, and velpatasvir is a BCRP substrate. Exposure to velpatasvir could increase modestly.
What this interaction means in plain words
Leniolisib and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Leniolisib belongs to Miscellaneous; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Leniolisib inhibits intestinal BCRP efflux, which increases velpatasvir absorption.
What to do
No dose adjustment is established; monitor for adverse effects of the HCV regimen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as minor. Leniolisib and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits BCRP, and velpatasvir is a BCRP substrate. Exposure to velpatasvir could increase modestly.
How serious is the interaction between Leniolisib and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is established; monitor for adverse effects of the HCV regimen.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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