Drug interactions
Leniolisib + Tizanidine
Severity: Moderate
Leniolisib and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is a weak CYP1A2 inhibitor and tizanidine is a sensitive CYP1A2 substrate. Increased tizanidine exposure can cause hypotension, bradycardia and excess sedation.
What this interaction means in plain words
Leniolisib and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Tizanidine belongs to Musculoskeletal.
Why it happens
Leniolisib inhibits CYP1A2, reducing tizanidine clearance.
What to do
Consider an alternative muscle relaxant. If both are required, start tizanidine at a low dose and monitor blood pressure, heart rate and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Tizanidine?
MediHelp rates the interaction as moderate. Leniolisib and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib is a weak CYP1A2 inhibitor and tizanidine is a sensitive CYP1A2 substrate. Increased tizanidine exposure can cause hypotension, bradycardia and excess sedation.
How serious is the interaction between Leniolisib and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative muscle relaxant. If both are required, start tizanidine at a low dose and monitor blood pressure, heart rate and sedation.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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