Drug interactions
Leniolisib + Voriconazole
Severity: Major
Leniolisib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase leniolisib exposure through CYP3A4 inhibition, increasing the risk of dose-related adverse effects.
What this interaction means in plain words
Leniolisib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Leniolisib belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of leniolisib.
What to do
Avoid strong CYP3A4 inhibitors with leniolisib where possible and choose another antifungal. If unavoidable, monitor for adverse effects and reduce the dose if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Voriconazole?
MediHelp rates the interaction as major. Leniolisib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole may increase leniolisib exposure through CYP3A4 inhibition, increasing the risk of dose-related adverse effects.
How serious is the interaction between Leniolisib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inhibitors with leniolisib where possible and choose another antifungal. If unavoidable, monitor for adverse effects and reduce the dose if needed.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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