Drug interactions
Lenvatinib + Pazopanib
Severity: Moderate
Lenvatinib and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both tyrosine kinase inhibitors can prolong the QT interval and cause hypertension and electrolyte disturbances. Combined use raises the risk of arrhythmia. Combining two multikinase inhibitors is also uncommon and adds overlapping toxicity.
What this interaction means in plain words
Lenvatinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation and overlapping VEGFR-related toxicity.
What to do
Monitor ECG closely and correct potassium, magnesium and calcium. Avoid combining unless clearly justified.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Pazopanib?
MediHelp rates the interaction as moderate. Lenvatinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both tyrosine kinase inhibitors can prolong the QT interval and cause hypertension and electrolyte disturbances. Combined use raises the risk of arrhythmia. Combining two multikinase inhibitors is also uncommon and adds overlapping toxicity.
How serious is the interaction between Lenvatinib and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG closely and correct potassium, magnesium and calcium. Avoid combining unless clearly justified.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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