Drug interactions
Lenvatinib + Safinamide
Severity: Minor
Lenvatinib and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide may inhibit intestinal BCRP, potentially increasing lenvatinib absorption. Higher lenvatinib exposure could worsen hypertension, proteinuria and fatigue.
What this interaction means in plain words
Lenvatinib and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenvatinib belongs to Oncology; Safinamide belongs to Central Nervous System.
Why it happens
Inhibition of BCRP efflux may increase lenvatinib absorption.
What to do
Monitor blood pressure and for lenvatinib adverse effects after safinamide is started. Reduce or interrupt the lenvatinib dose per labeling if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lenvatinib and Safinamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Safinamide?
MediHelp rates the interaction as minor. Lenvatinib and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide may inhibit intestinal BCRP, potentially increasing lenvatinib absorption. Higher lenvatinib exposure could worsen hypertension, proteinuria and fatigue.
How serious is the interaction between Lenvatinib and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for lenvatinib adverse effects after safinamide is started. Reduce or interrupt the lenvatinib dose per labeling if toxicity occurs.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
