Drug interactions
Lenvatinib + Sofosbuvir-velpatasvir
Severity: Minor
Lenvatinib and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits BCRP, but lenvatinib is only a P-gp and BCRP substrate with high bioavailability. Any increase is likely small.
What this interaction means in plain words
Lenvatinib and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenvatinib belongs to Oncology; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir may inhibit intestinal BCRP and P-gp efflux of lenvatinib.
What to do
Monitor for lenvatinib toxicity such as hypertension, proteinuria and diarrhea. Adjust dose per labeling if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Lenvatinib and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits BCRP, but lenvatinib is only a P-gp and BCRP substrate with high bioavailability. Any increase is likely small.
How serious is the interaction between Lenvatinib and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lenvatinib toxicity such as hypertension, proteinuria and diarrhea. Adjust dose per labeling if adverse effects occur.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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