Drug interactions
Lenvatinib + Sorafenib
Severity: Moderate
Lenvatinib and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use may increase the risk of arrhythmia. Both also cause hypertension and electrolyte disturbances that add to the risk.
What this interaction means in plain words
Lenvatinib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Obtain a baseline ECG and monitor it periodically. Correct potassium, magnesium and calcium abnormalities, and control blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Sorafenib?
MediHelp rates the interaction as moderate. Lenvatinib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined use may increase the risk of arrhythmia. Both also cause hypertension and electrolyte disturbances that add to the risk.
How serious is the interaction between Lenvatinib and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically. Correct potassium, magnesium and calcium abnormalities, and control blood pressure.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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