Drug interactions
Lenvatinib + Sunitinib
Severity: Moderate
Lenvatinib and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both kinase inhibitors can prolong the QT interval, and lenvatinib labeling advises close ECG monitoring with QT-prolonging drugs. They also share toxicities such as hypertension and hepatotoxicity.
What this interaction means in plain words
Lenvatinib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
Additive QT prolongation and overlapping toxicity profiles.
What to do
Monitor ECG, electrolytes, blood pressure and liver function regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Sunitinib?
MediHelp rates the interaction as moderate. Lenvatinib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both kinase inhibitors can prolong the QT interval, and lenvatinib labeling advises close ECG monitoring with QT-prolonging drugs. They also share toxicities such as hypertension and hepatotoxicity.
How serious is the interaction between Lenvatinib and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes, blood pressure and liver function regularly.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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