Drug interactions
Lenvatinib + Triptorelin
Severity: Moderate
Lenvatinib and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib is associated with QT prolongation, and triptorelin may add to this effect. The combination may increase the risk of arrhythmia, especially with hypokalemia or hypomagnesemia.
What this interaction means in plain words
Lenvatinib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Triptorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG periodically and correct potassium, calcium and magnesium. Withhold or reduce lenvatinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Triptorelin?
MediHelp rates the interaction as moderate. Lenvatinib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenvatinib is associated with QT prolongation, and triptorelin may add to this effect. The combination may increase the risk of arrhythmia, especially with hypokalemia or hypomagnesemia.
How serious is the interaction between Lenvatinib and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG periodically and correct potassium, calcium and magnesium. Withhold or reduce lenvatinib if QTc becomes markedly prolonged.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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