Drug interactions
Leriglitazone + Methotrexate
Severity: Moderate
Leriglitazone and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leriglitazone may raise methotrexate exposure through BCRP inhibition. This could increase myelosuppression, mucositis and hepatic or renal toxicity.
What this interaction means in plain words
Leriglitazone and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leriglitazone belongs to Central Nervous System; Methotrexate belongs to Oncology.
Why it happens
Inhibition of BCRP efflux transporter increases methotrexate absorption and reduces elimination.
What to do
Monitor blood counts, liver and renal function, and adjust the methotrexate dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Leriglitazone and Methotrexate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Leriglitazone
- Gemfibrozil + Leriglitazone Major
- Carbamazepine + Leriglitazone Moderate
- Clarithromycin + Leriglitazone Moderate
- Gliclazide + Leriglitazone Moderate
- Itraconazole + Leriglitazone Moderate
- Ketoconazole + Leriglitazone Moderate
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Leriglitazone with Methotrexate?
MediHelp rates the interaction as moderate. Leriglitazone and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leriglitazone may raise methotrexate exposure through BCRP inhibition. This could increase myelosuppression, mucositis and hepatic or renal toxicity.
How serious is the interaction between Leriglitazone and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver and renal function, and adjust the methotrexate dose if toxicity develops.
What other medicines interact with Leriglitazone?
MediHelp also lists interactions of Leriglitazone with, for example, Gemfibrozil, Carbamazepine, Clarithromycin. The full list is on the Leriglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
