Drug interactions
Lesinurad + Mefenamic acid
Severity: Moderate
Lesinurad and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid is a CYP2C9 inhibitor and lesinurad is cleared mainly by CYP2C9, so lesinurad exposure may rise. Higher lesinurad levels may increase the risk of renal adverse effects. Lesinurad has been discontinued in many markets.
What this interaction means in plain words
Lesinurad and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lesinurad belongs to Genitourinary; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2C9-mediated metabolism of lesinurad by mefenamic acid.
What to do
If the combination is unavoidable, monitor serum creatinine and renal function closely. Consider an alternative analgesic that does not inhibit CYP2C9.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Frequently asked questions
Can I take Lesinurad with Mefenamic acid?
MediHelp rates the interaction as moderate. Lesinurad and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid is a CYP2C9 inhibitor and lesinurad is cleared mainly by CYP2C9, so lesinurad exposure may rise. Higher lesinurad levels may increase the risk of renal adverse effects. Lesinurad has been discontinued in many markets.
How serious is the interaction between Lesinurad and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is unavoidable, monitor serum creatinine and renal function closely. Consider an alternative analgesic that does not inhibit CYP2C9.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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