Drug interactions
Lesinurad + Piroxicam
Severity: Minor
Lesinurad and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is metabolized mainly by CYP2C9, but piroxicam is a substrate and not a significant inhibitor of this enzyme. A meaningful rise in lesinurad exposure is unlikely, although both drugs can affect renal function.
What this interaction means in plain words
Lesinurad and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lesinurad belongs to Genitourinary; Piroxicam belongs to Musculoskeletal.
Why it happens
No established pharmacokinetic mechanism; theoretical competition at CYP2C9, with additive renal risk from NSAID use.
What to do
No dose change is needed for the enzyme effect. Monitor serum creatinine, as lesinurad carries renal adverse effects and NSAIDs may add to them.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Frequently asked questions
Can I take Lesinurad with Piroxicam?
MediHelp rates the interaction as minor. Lesinurad and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lesinurad is metabolized mainly by CYP2C9, but piroxicam is a substrate and not a significant inhibitor of this enzyme. A meaningful rise in lesinurad exposure is unlikely, although both drugs can affect renal function.
How serious is the interaction between Lesinurad and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed for the enzyme effect. Monitor serum creatinine, as lesinurad carries renal adverse effects and NSAIDs may add to them.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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