Drug interactions
Lesinurad + Tazemetostat
Severity: Minor
Lesinurad and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is a weak CYP3A inducer and could slightly reduce tazemetostat exposure, potentially lowering its efficacy. The effect is expected to be small.
What this interaction means in plain words
Lesinurad and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lesinurad belongs to Genitourinary; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by lesinurad increases tazemetostat metabolism.
What to do
No dose change is typically needed; monitor for reduced tazemetostat response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Tazemetostat
Frequently asked questions
Can I take Lesinurad with Tazemetostat?
MediHelp rates the interaction as minor. Lesinurad and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lesinurad is a weak CYP3A inducer and could slightly reduce tazemetostat exposure, potentially lowering its efficacy. The effect is expected to be small.
How serious is the interaction between Lesinurad and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically needed; monitor for reduced tazemetostat response.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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