Drug interactions
Letermovir + Memantine-donepezil
Severity: Minor
Letermovir and Memantine-donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir has variable effects on CYP3A, acting as a moderate inhibitor, and may raise donepezil concentrations because donepezil is a CYP3A4 and CYP2D6 substrate. Higher exposure could increase cholinergic effects such as bradycardia, nausea and vomiting.
What this interaction means in plain words
Letermovir and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Letermovir inhibition of CYP3A4 may reduce donepezil metabolism.
What to do
No empirical dose change is needed. Monitor for bradycardia, GI intolerance and syncope.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Memantine-donepezil?
MediHelp rates the interaction as minor. Letermovir and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir has variable effects on CYP3A, acting as a moderate inhibitor, and may raise donepezil concentrations because donepezil is a CYP3A4 and CYP2D6 substrate. Higher exposure could increase cholinergic effects such as bradycardia, nausea and vomiting.
How serious is the interaction between Letermovir and Memantine-donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for bradycardia, GI intolerance and syncope.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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