Drug interactions
Letermovir + Mifepristone
Severity: Moderate
Letermovir and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 and may raise mifepristone exposure. Mifepristone may also affect letermovir through hepatic transporter inhibition. Effects are predicted and probably modest.
What this interaction means in plain words
Letermovir and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Mifepristone belongs to Endocrine.
Why it happens
Letermovir inhibits CYP3A4, and mifepristone may inhibit OATP1B1/3 and CYP3A4-related clearance of letermovir.
What to do
Monitor for mifepristone adverse effects such as hypokalemia and QT prolongation. Monitor letermovir tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Mifepristone?
MediHelp rates the interaction as moderate. Letermovir and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 and may raise mifepristone exposure. Mifepristone may also affect letermovir through hepatic transporter inhibition. Effects are predicted and probably modest.
How serious is the interaction between Letermovir and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mifepristone adverse effects such as hypokalemia and QT prolongation. Monitor letermovir tolerability.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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