Drug interactions
Letermovir + Nicardipine
Severity: Moderate
Letermovir and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and can increase exposure to nicardipine. This may cause greater blood pressure reduction, edema and tachycardia during letermovir prophylaxis.
What this interaction means in plain words
Letermovir and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Nicardipine belongs to Cardiovascular.
Why it happens
Letermovir inhibits CYP3A4, decreasing nicardipine metabolism.
What to do
Monitor blood pressure and heart rate while on letermovir and reduce the nicardipine dose if hypotension occurs. Recheck after letermovir is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Nicardipine?
MediHelp rates the interaction as moderate. Letermovir and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A inhibitor and can increase exposure to nicardipine. This may cause greater blood pressure reduction, edema and tachycardia during letermovir prophylaxis.
How serious is the interaction between Letermovir and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate while on letermovir and reduce the nicardipine dose if hypotension occurs. Recheck after letermovir is stopped.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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