Drug interactions
Letermovir + Paclitaxel
Severity: Moderate
Letermovir and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits OATP1B1/3 and CYP3A4 and may increase paclitaxel exposure, which could worsen myelosuppression and neuropathy. Clinical data are limited.
What this interaction means in plain words
Letermovir and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Paclitaxel belongs to Oncology.
Why it happens
Letermovir inhibits OATP1B1/3 hepatic uptake and CYP3A4 metabolism of paclitaxel.
What to do
Monitor blood counts and neurotoxicity and reduce the paclitaxel dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Paclitaxel?
MediHelp rates the interaction as moderate. Letermovir and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits OATP1B1/3 and CYP3A4 and may increase paclitaxel exposure, which could worsen myelosuppression and neuropathy. Clinical data are limited.
How serious is the interaction between Letermovir and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity and reduce the paclitaxel dose if toxicity occurs.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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