Drug interactions
Letermovir + Quetiapine
Severity: Moderate
Letermovir and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A and may increase quetiapine exposure. This could heighten sedation, hypotension and QT prolongation, which matters in transplant patients with other risk factors.
What this interaction means in plain words
Letermovir and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Quetiapine belongs to Central Nervous System.
Why it happens
Letermovir inhibits CYP3A4-mediated quetiapine metabolism.
What to do
Monitor for sedation, hypotension and QTc prolongation, and reduce the quetiapine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Quetiapine?
MediHelp rates the interaction as moderate. Letermovir and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A and may increase quetiapine exposure. This could heighten sedation, hypotension and QT prolongation, which matters in transplant patients with other risk factors.
How serious is the interaction between Letermovir and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and QTc prolongation, and reduce the quetiapine dose if adverse effects occur.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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