Drug interactions
Letermovir + Ramelteon
Severity: Minor
Letermovir and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A4 inhibitor and may raise ramelteon exposure modestly. Ramelteon is mainly metabolized by CYP1A2, so the effect is expected to be limited, but increased next-day drowsiness is possible.
What this interaction means in plain words
Letermovir and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Ramelteon belongs to Central Nervous System.
Why it happens
Letermovir inhibits CYP3A4, a minor metabolic pathway for ramelteon.
What to do
No routine dose change is needed; ask the patient about excessive daytime sedation or dizziness and reduce the ramelteon dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Ramelteon?
MediHelp rates the interaction as minor. Letermovir and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir is a moderate CYP3A4 inhibitor and may raise ramelteon exposure modestly. Ramelteon is mainly metabolized by CYP1A2, so the effect is expected to be limited, but increased next-day drowsiness is possible.
How serious is the interaction between Letermovir and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; ask the patient about excessive daytime sedation or dizziness and reduce the ramelteon dose if these occur.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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